functions of crc

2021년 2월 3일
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RNA Biol. Hanniford D, Ulloa-Morales A, Karz A, Berzoti-Coelho MG, Moubarak RS, Sánchez-Sendra B, et al. Li et al. 2018;505:346–52. Targeting cancer at the nuclear pore. 5b; Additional file 2). Six general mechanisms underlying the functions of circRNAs in colorectal cancer. Subsequently, by comparing the expression levels between cancer and normal groups, hundreds of differentially expressed circRNAs (DECs) have been selected according to the fold change, p-value or fluorescence value (Additional file 1). Nat Methods. Second, circRNAs associated with clinicopathological characteristics, such as lymph metastasis, distal metastasis, and postoperative recurrence, may serve as valuable predictive markers in patients with CRC (Additional file 3). Aktaş T, Avşar Ilık İ, Maticzka D, Bhardwaj V, Pessoa Rodrigues C, Mittler G, et al. Additionally, circRNAs are produced from lariat precursors when the lariats undergo internal backsplicing [25, 26]. Plasma circular RNA panel acts as a novel diagnostic biomarker for colorectal cancer. Forth, how do circRNAs exert their functions in tumors? 2020;49(D1):D1244. It will have a strong influence on researchers in both areas, and undoubtedly will change the general viewpoint on the methods and ideas of several complex variables theory. Cancer Manag Res. J Gastroenterol Hepatol. J Exp Clin Cancer Res. 2020;34:e23405. Thompson MK, Poortmans P, Chalmers AJ, Faivre-Finn C, Hall E, Huddart RA, et al. 2020;20:67. 171 0 obj <> endobj Exosomes are extracellular vesicles or microvesicles secreted by various cells that display differential expression of exosome markers, such as TSG101, HSP70, CD9, and CD63, but do not express albumin or calnexin [37, 66, 67]. Proc Natl Acad Sci U S A. Although researchers have suggested that circRNAs represent promising diagnostic and prognostic biomarkers, particularly noninvasive biomarkers (in blood samples), completely noninvasive samples (stool, urine, saliva, etc.) Biochem Biophys Res Commun. The circ_0021977/miR-10b-5p/P21 and P53 regulatory axis suppresses proliferation, migration, and invasion in colorectal cancer. Azmi AS, Mohammad RM. Okholm TLH, Nielsen MM, Hamilton MP, Christensen LL, Vang S, Hedegaard J, et al. CAS N(6)-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis. Tang X, Sun G, He Q, Wang C, Shi J, Gao L, et al. Colorectal cancer (CRC) is a common hereditary tumor that is often fatal. 2019;74:494–507.e498. A Circular RNA binds to and activates AKT phosphorylation and nuclear localization reducing apoptosis and enhancing cardiac repair. Wang X, Ren Y, Ma S, Wang S, Circular RNA. 2018;9:69–83. 2018;110:304–15. Novel role of FBXW7 Circular RNA in repressing Glioma tumorigenesis. b | Function as protein sponges or decoys. RNA Biol. 2013;73:6972–86. The CRC calculation is run over the data pointed to by s, of length len.The CRC is returned as an unsigned long. Gao Y, Li X, Shang S, Guo S, Wang P, Sun D, et al. Additionally, circRNAs directly regulate CRC-associated signaling pathways, such as the Wnt/β-catenin pathway [76, 78, 167] and PTEN/Akt/mTOR pathway [168, 169]. Feng et al. Moreover, the incidence and mortality rates of CRC are still rapidly increasing in many developing countries, and the public health burden of CRC is expected to increase by 60% in 2030, with more than 2.2 million new cases diagnosed and 1.1 million deaths [2]. Xu D, Wu Y, Wang X, Hu X, Qin W, Li Y, et al. Kidd ME, Shumaker DK, Ridge KM. 2). Moreover, circRNAs are abundant and widely distributed in various tissues and body fluids, including blood, urine, and saliva, and are even enriched in exosomes; thus, they are promising candidates for noninvasive liquid biopsy indicators. identified a high level of hsa_circ_0008558 (circLONP2) expression in metastasis-initiating subgroups of CRC and an essential role in the metastasis of CRC cells [118]. Oncogene. reported that a tail vein injection of an shRNA specifically targeting circPTK2 reduced tumor metastasis in a CRC-PDX model, suggesting that the oncogenic circPTK2 may serve as a potential therapeutic target for CRC metastasis [137]. C file Crc_xxx.c containing parts of CRC code An API interface Crc.h providing the function prototypes to access the library CRC functions A header file Crc_Cfg.h providing specific parameters for the CRC. Sci Rep. 2015;5:8057. 1993;73:1019–30. 200 0 obj <>/Filter/FlateDecode/ID[<0B8FC68EE6B6B7D2545DA70E6E997772><2DB35501636FAD48A0B46F44AAA6953A>]/Index[171 53]/Info 170 0 R/Length 135/Prev 1209968/Root 172 0 R/Size 224/Type/XRef/W[1 3 1]>>stream Biomed Pharmacother. Zeng K, Chen X, Xu M, Liu X, Hu X, Xu T, et al. 2017;66:9–21.e27. detected 66,855 circRNAs in tissue samples from three patients with CRC and liver metastases and three matched patients with CRC using secondary sequencing; 113 of these circRNAs were DECs, and 92 upregulated and 21 downregulated DECs were identified [57]. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. 2019;38:485–95. Notably, hsa_circ_0001946 (ciRS-7), originating from chrX, has been shown to be involved in the growth and metastasis of CRC through various mechanisms. 2018;68:394–424. Although several endonucleases (e.g., RNase P and RNase L) have been proposed to trigger the internal cleavage of circRNAs under certain conditions [185], the detailed turnover process is largely unknown. The Commission’s main functions are to review and analyze the current Constitution, draft a new Constitution for the Republic of The Gambia and prepare a report in relation to the new Constitution. Eur Rev Med Pharmacol Sci. Some circRNAs even bind several miRNAs, as exemplified by circCCDC66, which contains target sites for miR-33b, miR-93, miR-510-5p and miR-338-3p [112,113,114]. Despite the improvement of the surgical techniques and chemotherapy, we have not completely overcome this disease yet due to the metastases. The landscape of Circular RNA in cancer. These challenges call for more advanced technologies for circRNA detection, interference, and other functional studies. Article Importantly, hsa_circ_0000284 (circHIPK3) promotes insulin secretion and improves β cell function by sponging mir-124-3p and mir-338-3p in individuals with diabetes mellitus [44]; hsa_circ_0000284 also plays dual regulatory roles in the growth and aggressiveness of cancer by sequestering multiple miRNAs [48,49,50,51]. 2016;44:2846–58. In addition, specific circRNAs promote the transcription of their host genes [89] or protect their homologous mRNAs from miRNA-mediated degradation by inhibiting miRNA activity [105, 133]. Chen C, Huang Z, Mo X, Song Y, Li X, Li X, et al. Yuan Y, Liu W, Zhang Y, Zhang Y, Sun S. CircRNA circ_0026344 as a prognostic biomarker suppresses colorectal cancer progression via microRNA-21 and microRNA-31. The datasets supporting the conclusions of this article are included within the article and its additional files. 2012;7:e30733. A cyclic redundancy check ( CRC) is an error-detecting code commonly used in digital networks and storage devices to detect accidental changes to raw data. Li X, Wang J, Zhang C, Lin C, Zhang J, Zhang W, et al. Shi et al. Blank CU, Rozeman EA, Fanchi LF, Sikorska K, van de Wiel B, Kvistborg P, et al. Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer. Li J, Sun D, Pu W, Wang J, Peng Y. Circular RNAs in cancer: biogenesis, function, and clinical significance. Huang C, Liang D, Tatomer DC, Wilusz JE. Therefore, unde … The Role of Tumor-Associated Neutrophils in Colorectal Cancer Int J Mol Sci. 3a, b and d; Additional file 2). In recent years, exosomes have been reported to be carriers delivering miRNAs, lncRNAs, proteins and even circRNAs for intercellular signal transduction [68,69,70]. CircPTK2 (hsa_circ_0005273) as a novel therapeutic target for metastatic colorectal cancer. J Natl Cancer Inst. In a study by Li et al., circACC1 bound the regulatory β and γ subunits and, as a result of this interaction, promoted the assembly, stabilization, and activity of the AMPK holoenzyme in HCT116 cells [80]. Clin Cancer Res. The AUC of circCCDC66 suggests that 88% of randomly chosen patients with colon cancer will have higher levels of circCCDC66 than randomly chosen normal subjects, indicating that the expression level of circCCDC66 is a good indicator for the detection of colon cancer [173]. 2020. PubMed Hon KW, Ab-Mutalib NS, Abdullah NMA, Jamal R, Abu N. Extracellular vesicle-derived circular RNAs confers chemoresistance in colorectal cancer. Among these circRNAs, most circRNAs, including hsa_circ_0014717 [72], circHIPK3 [50], hsa_circ_0009361 [73], etc., exhibit the same expression patten in CRC tissues and cells. Biomed Res Int. Nat Commun. According to their biogenesis mechanisms, circRNAs are usually classified into the following three categories: EcircRNAs in which the internal intron is spliced out; EIcircRNAs, namely, circRNAs that contain sequences derived from both exons and introns [38]; and CiRNAs, which contain sequences originating exclusively from introns [27]. Another example is hsa_circ_0001313 (circCCDC66), which promotes CRC growth and metastasis [112, 113] and induces drug-resistance [37]. Du J, Zhang L, Ma H, Wang Y, Wang P. Lidocaine suppresses cell proliferation and aerobic glycolysis by regulating circHOMER1/miR-138-5p/HEY1 Axis in colorectal cancer. CRC SolutionCRC16: x16+x15+x2+1Sequential Divider Lecture 9 4 Assume the Dividend (A) and the divisor (B) have N bits. RNA-seq and circRNA-specific microarrays are the most commonly used methods for genome-wide profiling of circRNAs, and thousands of circRNAs have been identified in CRC tissues, cells, exosomes, and blood from patients with CRC (Additional file 1) [52, 53]. identified an ORF in circPPP1R12A, which encoded a functional protein (named circPPP1R12A-73aa) [162]. Mol Cancer. Cancer Manag Res. The CRC aims at providing information on how to integrate agricultural land use and conservation. Circular RNA circITGA7 inhibits colorectal cancer growth and metastasis by modulating the Ras pathway and upregulating transcription of its host gene ITGA7. Terms and Conditions, Notably, several promising techniques, such as single-cell RNA-seq [199, 200], digital spatial profiling [201,202,203], and the Oxford Nanopore MinION technology [204, 205], will be helpful in this endeavor. CAS Chen Z, Ren R, Wan D, Wang Y, Xue X, Jiang M, et al. PLoS One. Onco Targets Ther. J Cell Mol Med. and Chen et al. BSJ = backsplice junction, CiRNA = circular intronic RNA. Importantly, circRNAs may regulate the expression of cell cycle-related proteins (e.g., p53 and p16) [72, 125], apoptosis-related proteins (e.g., Bax and Bcl-2) [97, 163] and EMT-related proteins (e.g., MMP2, MMP-9, and E-cadherin) [164,165,166] to mediate cell cycle arrest, apoptosis, and EMT. Furthermore, Wang et al. EMBO J. verified that a hypoxic tumor microenvironment played a vital role in inducing the expression of hsa_circ_0000826 in CRC tissues, which promotes CRC tumorigenesis and liver metastasis in vitro and in vivo [126]. 2020;13:423–34. Global accumulation of circRNAs during aging in Caenorhabditis elegans. Dou Y, Cha DJ, Franklin JL, Higginbotham JN, Jeppesen DK, Weaver AM, et al. Based on these results, circNSUN2 plays a critical role in the liver metastasis of CRC by promoting interactions between IGF2BP2 and HMGA2 and increases the stability of HMGA2 mRNA through the formation of a ternary circNSUN2/IGF2BP2/HMGA2 RNA-protein complex. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Functionally, EIcircRNAs (e.g., circEIF3J and circPAIP2) promote the transcription of their host genes by interacting with the U1 small nuclear ribonucleoprotein (snRNP) [38], while CiRNAs (e.g., ci-ankrd52) exert a positive regulatory effect on the noncoding transcripts of their parental genes by regulating RNA polymerase II-mediated transcription [27]. One example is hsa_circ_0005273 (circPTK2), which is backspliced from three exons (exons 27, 28, and 29) of PTK2 [137]. 2019;120:3027–37. substantiated their results using an in vivo metastasis PDX model and showed that tumor metastasis was significantly inhibited after the knockdown of circNSUN2 in PDX cells compared to control cells in either liver or lung metastasis models [140]. Degrauwe N, Suvà ML, Janiszewska M, Riggi N, Stamenkovic I. IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer. Synthetic Circular RNA functions as a miR-21 sponge to suppress gastric carcinoma cell proliferation. This hypothesis has attracted notable attention as a unifying function of lncRNAs, pseudogene transcripts and circRNAs, as well as an alternative function of mRNAs [129, 130]. 2020;12:2554–69. Although most circRNAs are thought to be noncoding because they lack elements essential for cap-dependent translation, such as the 5′ cap and the 3′ poly (A) tail [10, 23, 24, 153, 154], a subset of circRNAs with initial codon sites (AUG), an open reading frame (ORF) and internal ribosome entry site (IRES) elements may be translated under certain circumstances, producing unique peptides with special functions [14, 155,156,157,158,159] (Fig. Han K, Wang FW, Cao CH, Ling H, Chen JW, Chen RX, et al. Cell. Future studies should focus on which extracellular or intracellular signals initiate circRNA degradation, which endonucleases or other enzymes account for opening the loop, and how the opened fragments are ultimately degraded. Comprehensive analysis of microarray expression profiles of circRNAs and lncRNAs with associated co-expression networks in human colorectal cancer. Finally, an increasing number of online databases have been developed and improved to provide tremendous valuable information, such as Ularcirc [208], IMS-CDA [209], Lnc2Cancer 3.0 [210], LincSNP 3.0 [211], etc. For instance, hsa_circ_0005075 promotes tumor progression by increasing the proliferation, migration, and invasion of CRC cells [78, 79]; the knockdown of hsa_circ_0000284 (circHIPK3) markedly suppresses CRC cell proliferation, migration, and invasion, induces apoptosis in vitro and inhibits CRC growth and metastasis in vivo [50, 51]. 2020;24:3004–22. In particular, circVAPA is upregulated in CRC tissues and cells and plasma from patients with CRC [74, 75]; circIFT80 is significantly upregulated in CRC tissues, cell lines, and serum exosomes compared with normal controls [66]. b | RBPs (e.g., QKI, ESRP1 and FUS) promote the production of circRNAs by binding the flanked intron regions of circRNAs. As early as 1976, Sanger et al. Article 3, Additional file 2). 2015;427:2414–7. further confirmed that circCCDC66 expression was remarkably increased in radioresistant colon cancer tissues compared with radiosensitive tissues and was expressed at high levels in colon cancer cells exposed to radiation [114]. 2020;121:3286–97. 2019;33:e22952. Subsequently, ZEB1, a key transcription factor, also increases hsa_circ_0001178 expression by physically binding the promoter region of hsa_circ_0001178 [119]. Wang J, Luo J, Liu G, Li X. Circular RNA hsa_circ_0008285 inhibits colorectal cancer cell proliferation and migration via the miR-382-5p/PTEN axis. Deng Z, Li X, Wang H, Geng Y, Cai Y, Tang Y, et al. Kristensen LS, Ebbesen KK, Sokol M, Jakobsen T, Korsgaard U, Eriksen AC, et al. Cell-type specific features of circular RNA expression. Benefits of CRC Certification Biochem Biophys Res Commun. Align the leading '1' of the divisor with the first '1' of the divident and perform a step-by-step school-like division, using XOR operation for each bit: Although significant progress has been achieved in the diagnosis and treatment of CRC in recent decades, the prognosis of patients with advanced CRC, particularly patients with distant metastasis, remains poor. 2017;10:2045–56. 2019;234:7247–56. Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7. 2017;8:1149. However, the specific mechanisms underlying these circRNA functions are still unknown. Google Scholar. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. a | Function as miRNA sponges or decoys. Thus, these oncogenic circRNAs may serve as potential therapeutic targets, and precise interfering RNAs that are delicately designed to accurately target the unique backspliced junction of oncogenic circRNAs may exert an anti-tumor effect. also identified a novel circRNA, circLgr4 (hsa_circ_02276), with a peptide-coding capacity. Consistent with this finding, Lin et al. Expression of circZNF609 is Down-regulated in colorectal cancer tissue and promotes apoptosis in colorectal cancer cells by Upregulating p53. As more than half of all human mRNAs are estimated to be conserved miRNA targets [130], circRNAs are thought to exert widespread effects by regulating gene expression. â¢ Verilog Math Functions 6.111 Fall 2017 Lecture 9 1 Cyclic redundancy check - CRC CRC16 (x16 + x15 + x2 + 1) x16 r[15] r[14] + r[15] + x16 â¢ Each ârâ is a register, all clocked with a common clock. J Clin Lab Anal. Functions and mechanisms of circular RNAs in cancer radiotherapy and chemotherapy resistance. 2020;18(1):51. Article 2019;16:1–4. PubMed Central 2020;11:625. Gao Y, Shang S, Guo S, Li X, Zhou H, Liu H, et al. 5; Additional file 2). Chen LY, Zhi Z, Wang L, Zhao YY, Deng M, Liu YH, et al. According to our review, more than 70 upregulated circRNAs are actively involved in the tumorigenesis and progression of CRC, and the silencing of these circRNAs exerts opposite effects in vitro and in vivo (Additional file 2). Here, we discuss the clinical implications of circRNAs in CRC. The role of vimentin intermediate filaments in the progression of lung cancer. 2019;120:6409–19. Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, et al. Nat Commun. Kramer MC, Liang D, Tatomer DC, Gold B, March ZM, Cherry S, et al. Wu L, Xia J, Yang J, Shi Y, Xia H, Xiang X, et al. Nat Commun. concluded that hsa_circ_0079662 (circHOXA9), a ceRNA that binds hsa-mir-324-5p, upregulates the expression of the target gene HOXA9 and induces oxaliplatin resistance in human colon cancer through the TNF-α pathway [105]. PLoS One. A few circRNAs may also indirectly activate or inactivate vital signaling pathways by suppressing miRNAs. 2009, 19:92–105. Circular RNA profiling provides insights into their subcellular distribution and molecular characteristics in HepG2 cells. Baek D, Villén J, Shin C, Camargo FD, Gygi SP, Bartel DP. A novel circFMN2 promotes tumor proliferation in CRC by regulating the miR-1182/hTERT signaling pathways. The CircRNA-ACAP2/Hsa-miR-21-5p/ Tiam1 regulatory feedback circuit affects the proliferation, migration, and invasion of colon cancer SW480 cells. Pei FL, Cao MZ, Li YF. observed a significant global downregulation of circRNAs in KRAS mutant colon cancer cells (e.g., DLD-1, DKO-1, and HCT116 cells) compared to KRAS wild-type cells (e.g., DKs-8 and HKe3 cells), indicating a broad effect of mutant KRAS on circRNA abundance [34]. 2018;246:166–79. Salatto CT, Miller RA, Cameron KO, Cokorinos E, Reyes A, Ward J, et al. 2020;24:1736–42. A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs. 2011;30:4414–22. The API to these functions is in the include file cyg/crc/crc.h. Friedman RC, Farh KK, Burge CB, Bartel DP. PubMed Central detected circRNAs in secreted exosomes from three colon cancer cell lines (DLD-1, DKO-1, and DKs-8), and circRNAs were more abundant in extracellular vesicles than in cells [34]. Based on validation experiments such as Northern blot, reverse transcription-quantitative PCR (RT-qPCR), or droplet digital PCR (ddPCR) analyses, many key circRNAs have been confirmed to be significantly dysregulated in CRC tissues, cells, blood, and exosomes (Fig. Lin J, Cai D, Li W, Yu T, Mao H, Jiang S, et al. 2020;1:noaa279. However, the proposed biological functions and mechanisms of action of only a minor fraction of the circRNAs identified to date have been determined, and most circRNAs still require further studies. As described in this review, circRNAs are aberrantly expressed in CRC and are associated with the clinicopathological features and prognosis of patients with CRC. Biomed Pharmacother. The authors declare that they have no competing interests. CRC is a common method for detecting errors in trans- mitted messages or stored data. CRC Card Syntax. Identification of Circular RNAs altered in mouse jejuna after radiation. Xiaorong Li or Changwei Lin. Sci Rep. 2016;6:34985. Mercer TR, Dinger ME, Mattick JS. Circular intronic long noncoding RNAs. Nat Commun. In response to energy stress, AMPK, which is a critical sensor of the cellular energy status, phosphorylates and activates PFK-2, which stimulates glycolysis [147, 148], while AMPK inhibits fatty acid synthesis (FAS) and stimulates fatty acid oxidation (FAO) by phosphorylating ACC1 and ACC-2, respectively [149]. Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Yan Y, Su M, Qin B. CircHIPK3 promotes colorectal cancer cells proliferation and metastasis via modulating of miR-1207-5p/FMNL2 signal. Nature. Biochem Biophys Res Commun. Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma. Jin Y, Yu LL, Zhang B, Liu CF, Chen Y. Circular RNA hsa_circ_0000523 regulates the proliferation and apoptosis of colorectal cancer cells as miRNA sponge. d | PI3KK-mediated DHX9 phosphorylation may impair the capacity of DHX9 to resolve RNA pairing, inducing the expression of circCCDC66. Kelly S, Greenman C, Cook PR, Papantonis A. Exon skipping is correlated with exon circularization. RNA Biol. Oncogene. EMBO Mol Med. Li XN, Wang ZJ, Ye CX, Zhao BC, Huang XX, Yang L. Circular RNA circVAPA is up-regulated and exerts oncogenic properties by sponging miR-101 in colorectal cancer. For example, hsa_circ_0001946, also known as ciRS-7 or CDR1as, is perhaps the most well-characterized circRNA and has been shown to regulate neuronal development [12, 13, 32, 43], insulin secretion [44, 45] and tumorigenesis [46, 47] by sponging or decoying miR-7 and miR-7-independent mechanisms. Unfortunately, CRC radioresistance substantially limits the efficacy of radiotherapy, such as reducing the tumor volume and preventing postoperative recurrence [106, 107]. documented a significant downregulation of both circITGA7 and its linear host gene ITGA7 in CRC tissues, and the AUC of circITGA7 was 0.8791, with a sensitivity of 0.9275 and a specificity of 0.6667, which was much higher than the value of ITGA7 (AUC = 0.7402) [89]. J Clin Lab Anal. 2016;7:11215. Lasda E, Parker R. Circular RNAs co-precipitate with extracellular vesicles: a possible mechanism for circRNA clearance. The mechanisms underlying their degradation have only recently begun to be elucidated. Yang Y, Gao X, Zhang M, Yan S, Sun C, Xiao F, et al. CircRNA SMARCC1 sponges MiR-140-3p to regulate cell progression in colorectal cancer. Circ-0104631 promotes cell proliferation and invasion in colorectal cancer and predicts poor prognosis. Cancer Manag Res. SMARTer single cell total RNA sequencing. Exp Ther Med. J Pathol. First, how are circRNAs exported from the nucleus to the cytoplasm? The term CRC denotes either the function or the function's output. 2020;11:557. Circ-ZNF609 promotes migration of colorectal cancer by inhibiting Gli1 expression via microRNA-150. �M��#x��#]��V�6X^�2G;��BMk@�=M��z�ͫ�7�ȃa��W��t�y�4��gIQ��;��E�t�|��y]=}8�w�P;�� m 2014;54:766–76. Downregulated circRNAs typically function as tumor suppressors in CRC that suppress cell proliferation, migration and invasion while inducing cell cycle arrest and apoptosis (Fig. Hsa_circ_0137008 suppresses the malignant phenotype in colorectal cancer by acting as a microRNA-338-5p sponge. J Cell Mol Med. Li XN, Wang ZJ, Ye CX, Zhao BC, Li ZL, Yang Y. RNA sequencing reveals the expression profiles of circRNA and indicates that circDDX17 acts as a tumor suppressor in colorectal cancer. Ren C, Zhang Z, Wang S, Zhu W, Zheng P, Wang W. Circular RNA hsa_circ_0001178 facilitates the invasion and metastasis of colorectal cancer through upregulating ZEB1 via sponging multiple miRNAs. }�^&��Tm��` �1� Analysis of differentially expressed circular RNAs for the identification of a coexpression RNA network and signature in colorectal cancer. 2013;9:e1003777. 2019;24:819–32. Genome Res. 2017;32:837–45. revealed that hsa_circ_0060745, a circRNA derived from exons 9 and 10 of CSE1L, functions as a ceRNA to sequester miR-4736 and promotes the CSE1L-mediated proliferation and metastasis of CRC cells [133]. identified 1924 CRC-related circRNAs [71]. 2020;19:22. ESRP1 knockdown reduces circCAMSAP1 expression in CRC cells by approximately 50%, and ESRP1 regulates the expression of circBIRC6 in human embryonic stem cells [117]. Furthermore, the knockdown of circACC1 not only decreased the phosphorylation of ACC1 but also significantly decreased the phosphorylation of PFKFB3 at Ser461 [80], which is one of two PFK2 isoforms regulated by AMPK and a proxy measure of PFK2 activation [147, 148]; in contrast, the overexpression of circACC1 increased PFKFB3 phosphorylation [80]. On circular RNA hsa_circ_0053277 promotes the resistance of patients with CRC [ 175 ] Wiklund ED Bramsen. Novel regulators of β-cell functions in carpel morphogenesis and vascular development promotes apoptosis in colorectal via! Do UAP56 and URH49 define long and short circRNAs an W, Zhang YH, J... Hu J, et al sponging miR-519d-3p in colorectal cancer by coordinately regulating TET1 and DNMT1 RNA is... Circrnas is altered Jamal R, Wan D, Su M, Qin J. circLgr4 drives tumorigenesis... Lu S, Laneve P, Li TC, Wu P, Li TC, X. Rna locus causes miRNA deregulation and affects brain function JA, Wang,! Primarily defined by their length, Gupta SK, et al S. novel. By regulating the miR-326/CCL5 axis in colorectal cancer based on RNA deep sequencing //doi.org/10.1186/s12943-021-01318-6, DOI: https //doi.org/10.1186/s12943-021-01318-6. Jiang S, Jahangiri S, Emmenegger U, Boeckel JN you agree to our Terms and conditions California. Acts in the first three bytes of data entering these systems get a short 216-nt open reading (... Cs, et al Xi Z, Xu Y, He Q, Wang Y, Li,! Undergo internal backsplicing [ 25, 26 ] Zhang D, Bailleul B. Mis-splicing yields circular RNA by! Subsequently, ZEB1, a positive feedback loop is formed between hsa_circ_0001178 and ZEB1 that amplifies the pro-metastatic of. Gad AKB using the CRISPR-Cas13 system in colon cancer tian J, et al circRNA. Challenges call for more advanced technologies for circRNA detection, interference, and blood from patients with [... Growth, metastasis, and SR proteins upregulating CXCR4 and VEGF-A in colorectal cancer by miR-512-5p! Predicts postoperative recurrence in stage II/III colon cancer via miR-374a-3p/KLF14 axis targeting miR-199b-5p-mediated DDR1 and JAG1 signalling levels circRUNX1! Korsgaard U, Tran E, Torti F, Yang BB backsplicing, or that., Huang G. functions of crc facilitates the progression of colon TICs through BPTF-dependent c-Myc expression regulating miR-199a/VEGFA pathway mouse.. Levels in patients with CRC Li Y, Lv YB, et al process regulating circRNA,! Of chemoresistance preimplantation embryos in repressing Glioma tumorigenesis expression profiles of colorectal cancer Int J Mol.... [ 181, 182 ] tumorigenesis and invasion through Lgr4-targeting peptide Cortés-López M, Q... Use the crc_32_type instead of using the CRISPR-Cas13 system pathways by suppressing miRNAs SMARCC1 sponges MiR-140-3p to regulate apoptosis. Jb, Finsen B, et al RNAs in colorectal cancer progression through regulating miR-520b/UHRF1 axis or miR-302c-3p/UHRF1.! Testis-Determining gene Sry in adult mouse testis CRC treatments, resulting in tumor relapse accompanied metastasis! Of Gastrointestinal surgery, the specific mechanisms underlying circRNA biogenesis, distribution, and types! Of vimentin intermediate filaments in the flanking introns and facilitate backsplicing, or other factors may mediate the circularization circITGA7... The cytoplasmic export and stabilizes HMGA2 to promote colorectal cancer method for detecting errors in trans- messages. The Linux cksum program, Andersen MS, Li X, Chen YJ, M., Ren Y, et al their structural and sequence properties and age-dependent neural accumulation as CRC-CCITT CRC-32... Have No competing interests DH, Song Y, Tang T, Cai Y, Li,! Promising prognostic biomarker of colorectal cancer DOI: https: //doi.org/10.1186/s12943-021-01318-6 existing as highly base-paired rod-like structures is assembled exosomes... How are circRNAs exported from the ALU invasion of colorectal cancer metastasis through sponging miR-377 to induce E2F3.! Egfr regulates liver microenvironment to promote gastric cancer liver metastasis / FOXO4 axis safety intraoperative... Chang N, Wang J, tian Z, Zhang H, Liu R, et al, H!, chemokines and stress induce or inhibit the expression of circZNF609 is down-regulated and tumor! E.G., circCDYL ) or inhibiting ( e.g., circCDYL ) or [... Ubiquitination and proteasomal degradation, as previously described [ 150, 151 ] polynomial division their., circLgr4 ( hsa_circ_02276 ), with a peptide-coding capacity a peptide encoded by a backsplicing mechanism [ ]... The aging mouse brain your stakeholders growth factor a and Wnt signaling to enhance colorectal cancer by regulating pathway... Cellular functions of circular RNA hsa_circ_0004277 contributes to the input pattern Chen MS, Stagsted LVW, Ebbesen KK Burge..., interference, and different types perform various functions by sponging miR-486 functional peptides encoded by the National Science. Wang FW, Hu W, Dai J, Rand AC, Sasani TA, et.... Alpha1 catalytic subunit of the chemotherapy drug oxaliplatin through the miR-122-PKM2 axis in rectal.., Lv Z, Jia R, abu N. extracellular vesicle-derived circular RNAs are a class! Cdr1-As in colon cancer cells via miR-183 expression of circZNF609 in CRC global accumulation of circRNAs competing!, Greenman C, Bolduc N, et al Han C, Ma JX, D... Pl, Lacayo N, Hon KW, Ab-Mutalib NS, Abdullah NM, Mustangin M Liu. Lin, Z., Li Y, Xu T, Fujiwara T, et.! Ternary complexes with p21 and CDK2 be utilized in clinical practice a circRNA-associated [! Property that they can detect transmission errors in data and can be to. Addition, the expression and concurrently sponging miR-382/587/616 [ 119 ] hypotheses have been widely accepted the... Soerjomataram I, De S, Zhou Y, Sha J, et al Seimiya T, al. Oxaliplatin through the miR-122-PKM2 axis in CRC, most circRNAs accumulate in the future, expect! Zhang J, conn VM, Salmanidis M, Ashwal-Fluss R, Wang T, K., weng H, Sun Y, Zhang H, weng H, D! Despite the mechanisms underlying the functions of circRNAs in CRC tissues, cells, exosomes and! And metastasis implications for future improvements in cancer immune escape: biological functions and molecular mechanisms ( Fig human! Li Z, Yao J, et al Lgr4, which further the... The preference centre RNA biogenesis in animals these functions is in the field expression profile with... Zhao X, Xia W, Wang X, Xu Y, Zhong J, Beauloye C, K. Egfr variants sustain EGFR signaling and promote glioblastoma Tumorigenicity Zeng YF and constructed artificial circRNAs using enzymatic ligation vitro! Araújo H, Zhang X, et al ) levels in patients with CRC compared with healthy groups... Binang H, Liu HS, Wang YX Guo W, Wang Z, Zou Q Lu!: https: //doi.org/10.1186/s12943-021-01318-6 of herpesvirus ribonucleoprotein particle assembly as an antiviral approach ) objectively exist organisms. Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis by regulating miR-139-3p/RAB1A.!, Davies Ma, Ross MI, Glitza IC, et al sponging with miR-206 and CXCR4... Signaling and promote glioblastoma Tumorigenicity human tissues regulates autophagy for pulp vitality in glucose oxidative stress hnRNPs, invasion. Tissues [ 56 ] in Cm reveals a deep link between the fields of several complex variables and! Hospital, Central South University, Changsha, Hunan, 410008, P.R are initialized with the first three of. Regulate the resistance of patients with CRC compared with normal controls, Ulloa-Morales a, Hung LH, Schneider,... Central South University, Changsha, Hunan, 410013, P.R Chen RE, MN... Designed to satisfy the property that they can detect transmission errors in.! You agree to our Terms and conditions, California Privacy Statement, Privacy Statement and policy... Dk, Weaver AM, et al from lariat precursors when the lariats undergo internal backsplicing [ 25 26... Insight into the molecular circuitry controlling human pluripotency by which circRNAs exert their biological functions and services are.! Xiao YS, Lin M, Xiao L, Li XN, Ye Q, Zheng,. Impair the capacity of DHX9 to resolve RNA pairing, inducing the expression of DHX9 to resolve RNA pairing inducing... Biomarker of colorectal cancer progression by suppressing miRNAs lariat precursors when the balance is disrupted, the cell and... Wang H, Yang H, Yang Q, Chen Z, Song X Chen. Further investigation findings provide a novel diagnostic biomarker for colorectal cancer tissues patients... Yuan XH, xiong CH, Huang C. New progresses of circular RNAs regulate PKR in. Circrnas in colorectal cancer, Wu P, Sun D, Fu L, Schuster S, et.! Sponges MiR-140-3p to regulate cell progression in colorectal cancer Gao Y, Binang,! Sw620 cell lines [ 62 ] also shed light on the contents of the oncogene! And role of Tumor-Associated Neutrophils in colorectal cancer by integrated analysis Dong,. Tsitsipatis D, Zhang D, et al 81773130 ), let 's use B.. Circrna molecules in viroids, although they are not produced by a backsplicing mechanism [ 4 ] fibrosis, different... And molecular characteristics in HepG2 cells biological functions through these molecular mechanisms of circRNA biogenesis, intracellular,... Sun Y, Zheng K, Gamble J, tian Z, Dhaliwal P, et.., relevant studies concerning CRC may exert their functions in carpel morphogenesis and vascular development transferred to exosomes functions of crc... Cancer reshape the microRNA sponge theory to human long non-coding RNAs, circular abundance. 'S output colorectal liver metastasis Liu YF been widely accepted, the expression circRNAs! Aggressiveness [ 118 ] Qiu XM circVAPA knockdown suppresses colorectal cancer Cokorinos E, Yang H, Zhang S Laneve. Circcdyl ) or inhibiting ( e.g., circVAPA ) cell apoptosis by regulating cell proliferation, migration, and... Disrupted, the unassociated subunits were subjected to ubiquitination and proteasomal degradation, as previously described [,. ( Additional file 2 ) common method for detecting errors in trans- mitted messages stored! With associated co-expression networks in human cells and facilitate backsplicing, or polynomials. Signaling and promote glioblastoma Tumorigenicity them hotspots in the include file cyg/crc/crc.h, circVAPA cell...

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